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Inventi Impact: Biomedical Analysis

Articles

  • Inventi:pba/31367/20
    Simultaneous Quantitation of S(+)- and R(â??)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid Using LCâ??APCIâ??MS/MS: An Application for Clinical Studies
    Research 2020 : April - June
    Qingfeng He, Yashpal S Chhonker, Matthew J McLaughlin, Daryl J Murry

    Baclofen is a racemic mixture that is commonly used for the treatment for spasticity.\nHowever, the optimal dose and dosing interval to achieve effective cerebral spinal fluid (CSF)\nconcentrations of baclofen are not known. Moreover, it is unclear if there are differences in the ability\nof R- or S-baclofen to cross the bloodâ??brain barrier and achieve effective CSF concentrations. We have\nvalidated a liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method\nwith improved selectivity and sensitivity for the simultaneous quantitation of R- and S-baclofen\nand metabolites in plasma and CSF. ..........................

    How to Cite this Article
    Attribution/ CC Compliant Citation: He, Qingfeng, et al. \"Simultaneous Quantitation of S (+)-and R (â??)-Baclofen and Its\nMetabolite in Human Plasma and Cerebrospinal Fluid using LC -APCI -MS/MS: An Application for Clinical Studies.\"\nMolecules 25.2 (2020): 250.\nhttps://doi:10.3390/molecules25020250\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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